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Home | Seminars and Symposia | Past seminars/symposia: Wednesday, December 19, 2001

DTC Seminar Series

Computational Design of a Functional Protein: a Toy Model

by

Alexander Grosberg
Physics and Biophysics

Wednesday, December 19, 2001
1:00 pm

Room 56 Architecture (lower level)

In this talk, Dr. Grosberg discussed the general computational strategies employed to design sequences and conformations of model proteins. This includes methods mimicking real evolution in the sequence space, and other methods pretending to shortcut the sequence evolution. In the latest development, they have successfully designed a simple (lattice) toy model in which several conformations of particularly low energy for the designed sequence form a one dimensional path along which the system can orderly move, thus mimicking a motor-like function.

 

Alexander Grosberg was born in Moscow in 1949. He graduated from Moscow State University in 1972, received his Ph.D in 1975, and the next degree called doctor of science (similar to a full professorship in the US) in 1982. Dr. Grosberg is the author of about 170 scientific papers and 4 books. He works in theoretical and computational physics of polymers, biopolymers, complex systems, and soft condensed matter.