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Home | DTI | 2007–08 funded proposals | Susanta K Hui, Nikos Papanikolopoulos, Tom D. Whitaker

Initiatives in Digital Technology: 2007–08 Funded Proposals

Susanta K Hui, Nikos Papanikolopoulos, Tom D. Whitaker

An Optical Vision System for a Closed-loop Real-time Body Motion Tracking Instrument for Advanced Radiation Treatment

Total body irradiation (TBI) is a widely used pre-conditioning regimen for hematopoietic stem cell transplantation (HCT). Patients who are not in hematological remission are still at a high risk for treatment related mortality (TRM) and have a low probability for disease free survival (DFS). Increased TBI dose significantly reduces the risk of relapse, but increases organ toxicity and transplantation-related mortality (TRM). To overcome toxicities and to facilitate dose escalation, we developed a novel image-guided highly conformal total marrow irradiation (TMI) method using Tomotherapy. The TMI treatment procedure is very long (approximately one and half hours). It requires pre-treatment megavoltage CT (MVCT) scans for whole body localization, followed by Tomotherapy treatment delivery to the entire axis of the bone marrow. Patients are expected to remain motionless during this entire period. There is presently no system to monitor whether patients move during these long treatment procedures. This is a great concern for patient safety, because patient movement can cause inaccurate radiation delivery. The solution to this problem mandates the development of a closed loop monitoring system that is based on digital technology principles. We propose to develop a closed loop optical vision system that will (i) reduce treatment localization time, (ii) monitor patient movement during treatment (intra-fraction) time, (iii) enhance treatment related safety, and (iv) offer valuable information augmenting adaptive conformal delivery by systematically monitoring patient inter-fraction and inter-fraction body motion.