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Home | Seminars and Symposia | Past seminars/symposia: Tuesday, July 15, 2014

DTC Seminar Series

Computational Analysis and Applications of Diffusion MRI


Christophe Lenglet
Department of Radiology
University of Minnesota

Tuesday, July 15, 2014
12:30 p.m. reception
1:00 p.m. seminar

405 Walter Library

Christophe Lenglet

Diffusion Magnetic Resonance Imaging (MRI) provides unprecedented insights into the "wiring" of the human brain. This non-invasive imaging technique, introduced in the mid-1980s, uses diffusing water molecules as microscopic probes for the three dimensional structure of axonal pathways. Large international consortia such as the Human Connectome Project (HCP) are currently underway to exploit diffusion MRI, in conjunction with other structural and functional imaging modalities, and ultimately elucidate the brain circuitry. Diffusion MRI raises many mathematical and computational challenges, because of the complexity of the data and the need for adequate models. In this talk, I will give an overview of the basic concepts behind this imaging modality, address topics such as white matter fiber orientation mapping and tractography, and describe their application to the study of neurodegenerative diseases.


Christophe Lenglet is a McKnight Land-Grant Assistant Professor in the department of Radiology at the University of Minnesota. He is a faculty member of the Center for Magnetic Resonance Research, and a Scholar of the Institute for Translational Neuroscience. Christophe received a Ph.D. in Biomedical Imaging from INRIA Sophia Antipolis-Mediterranee (France) in 2006. His lab develops computational tools to harness the power of high-field Magnetic Resonance Imaging (MRI) for neuroscience and clinical applications. His research aims at better understanding the structural and functional alterations of brain connections in neurodegenerative disorders.