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Home | Seminars and Symposia | Past seminars/symposia: Friday, September 21, 2012

Dynamics and Mechanisms of UV-Damaged DNA Repair by Photolyases


Dongping Zhong
Robert Smith Professor of Physics
The Ohio State University
Columbus, Ohio

Friday, September 21, 2012
2:00 pm

402 Walter Library

ZhongUltraviolet irradiation causes DNA damages and leads to genome mutation and potential skin cancer. However, such damage can be restored completely by photolyase enzyme in nature with blue light. Using femtosecond spectroscopy and molecular biology, we report here the real-time studies of completely repair processes at the most fundamental level and thus reveal the repair photocycle and elucidate the molecular mechanism of repair and high efficiency.


Dongping Zhong received his B.S. in laser physics from Huazhong University of Science and Technology, China, and his Ph.D. in Chemistry from California Institute of Technology in 1999 under Prof. Ahmed H. Zewail. Dr. Zhong received the Herbert Newby McCoy Award and the Milton and Francis Clauser Doctoral Prize from Caltech for his Ph.D. work. He continued his postdoctoral research in Zewail's group with a focus on protein dynamics. In 2002, he joined the Ohio State University as an Assistant Professor. Currently Dr. Zhong is Robert Smith Professor of Physics and Professor of Chemistry and Biochemistry. He is the Packard Fellow, Sloan Fellow, Camille Dreyfus Teacher-Scholar, APS Fellow, AAAS Fellow, as well as the recipient of the NSF CAREER award. His research interests include biomolecular interactions and ultrafast protein/enzyme dynamics.