University of Minnesota
University Relations
myU OneStop

Go to unit's home.

Home | Seminars and Symposia | Past seminars/symposia: Thursday, March 16, 2006

Dude, Where is my genome? How to Build a Cheap Whole Genome Haplotypic Sequencer.


Bud Mishra
Professor of Computer Science and Mathematics
Courant Institute

Thursday, March 16, 2006
11:00 am

405 Walter Library

Download slides (pdf 5.64 MB) In this talk, I will describe the basic technologies, experiment design and algorithmic analysis needed to build an effective single molecule platform. I will start with the basic optical-mapping platform, which has been used for restriction maps for clones, whole-genomes and difficult-to-sequence regions of human genome (e.g., Y-chromosome). I will also describe how we plan to successively improve it to do haplotypes, chromosomal aberration maps, personal sequencing, methylation pattern maps, expression profile, and alternative-splicing measurements. I will describe few applications to oncogenomics, and related areas.


Prof. Bud Mishra is a professor of computer science and mathematics at NYU’s Courant Institute of Mathematical Sciences and a professor of cell biology at NYU School of Medicine. He founded the NYU/Courant Bioinformatics Group, a multi-disciplinary group working on research at the interface of computer science and biology. He has developed several sophisticated technologies, algorithms, and statistical analysis tools to attack biological problems that range from deciphering the structure of a genome to understanding chromosomal aberrations and their relation to cancer genetics. Prof. Mishra has a degree in Physics from Utkal University, in Electronics and Communication Engineering from IIT, Kharagpur, and MS and PhD degrees in Computer Science from Carnegie-Mellon University. He has industrial experience in Computer Science (Tartan Laboratories, and ATTAP), Finance (Tudor Investment and PRF, LLC), Robotics and Biotechnology (OpGen, and Bioarrays). His research has ranged from compilers, algorithms and complexity, logic, and algebra to robotics, finance, internet, and biology. He also holds adjunct professorships at Tata Institute of Fundamental Research and Mt. Sinai School of Medicine. From 2001–04, he was a professor at the Watson School of Biological Sciences, Cold Spring Harbor Lab.